Extended Data Fig. 3: Overexpression but not knockout of Ang selectively affect RGTTCRA-tRF levels which also correlate to Lewy bodies score in PD blood. MT-tRNA are reduced with PD duration. | Nature Aging

Extended Data Fig. 3: Overexpression but not knockout of Ang selectively affect RGTTCRA-tRF levels which also correlate to Lewy bodies score in PD blood. MT-tRNA are reduced with PD duration.

From: Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments

Extended Data Fig. 3

a. KO of Ang (green) in U2SO cells with or without sodium arsenite (SA) exposure (purple and grey). Y axis: percentage of RGTTCRA-tRFs out of all expressed tRFs. b. As A. for MT-tRFs percentage. Both A and B were analyzed with a two-way ANOVA test that yielded no significant results. c. SN samples of healthy controls with (grey) or without (pink) healthy-reflecting levels of TH in their SN, compared to PD patients (blue) and SWEDD-like patients (orange) from a cohort of NBB Long-RNA-seq (n = 25). Y axis: Log10 of sum of all expressed MT-tRNAs. X axis: PD duration in years. r = 0.4, p < 0.05, Spearman correlation; PD vs. Ctrl p < 0.039 two-sided Mann-Whitney test. All boxplots in this figure are defined so that the central line of the boxplot represents the median, the lower and upper box bounds represent 0.25 and 0.75 quantiles and lower and upper whiskers bounds represent 0 and 1 quantiles.

Back to article page