Extended Data Fig. 6: Baz2b regulates the expression of genes related to lipid metabolism.
From: Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
a, Heatmap showing DEGs in livers from young and aged WT, Baz2b+/− and Baz2b−/− mice. b, Top gene-ontology (GO) terms of DEGs in livers between young and aged WT mice. c, GO terms of DEGs in livers between aged WT and aged Baz2b−/− mice. d, Heatmap showing DEGs in livers from WT, Baz2b and Baz2b−/− mice fed with chow diet (control) or CDAHFD for 8 weeks. e, GO terms of DEGs in livers between WT mice fed with chow diet or CDAHFD for 8 weeks. f, GO terms of DEGs in livers between WT and Baz2b−/− mice fed with CDAHFD for 8 weeks. g, h, qPCR analysis of expression levels of genes related to the Ppara signal pathway and immune response in livers from indicated aged (g) or MASH WT mice (h). Red font highlights DEG with P < 0.05. n = 3 mice for each group and experiments were repeated 3 times. i-j, Western blot images (i) and quantitative analysis (j) of the Pparα, Acsl1, and Cpt1α proteins in livers from young and aged WT, Baz2b+/− and Baz2b−/− mice fed with chow diet. Protein levels were normalized to the level of individual protein in livers of WT young control mice. The numbers of tested mice were indicated in parentheses. Each data point represents a value from one mouse, data are means ± s.e.m.*P < 0.05, **P < 0.01, ***P < 0.001; ns, not significant; One-way ANOVA test with Dunnett’s test was used.
