Extended Data Fig. 7: Hepatocyte-specific knock-down of Pparα restores MASH pathologies in Baz2b−/− mice.
From: Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
a, b, Representative images of CD11b, F4/80, and αSMA (a) immunostaining in liver sections and their quantifications (b). Scale bars, 50 μm. c, Western blot analysis of the level of proteins related to the Ppara signaling pathway. n = 3 independent experiments. Protein levels were normalized to the level of individual protein in livers of WT control mice. d-f Quantitative analysis of body weight (d), liver weight (e), and the ratio (%) of liver to body weight (f) in mice with hepatocyte-specific knock-down of Ppara. The numbers of tested mice were indicated in parentheses. Each data point represents a value from one mouse. All data are means ± s.e.m. *P < 0.05, **P < 0.01 and ***P < 0.001; ns, not significant. One-way ANOVA with Dunnett’s post-test was used for b-f.
