Extended Data Fig. 8: BAZ2B influences chromatin accessibility.
From: Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
a, Heatmap of normalized read densities around a 3 kb window upstream and downstream of the TSS for BAZ2B-occupied genes. ChIP-seq analysis of BAZ2B binding DNA regions in AML12 hepatocyte cells expressing Flag-tagged BAZ2B was performed using anti-Flag antibodies. AML12 cells expressing empty plasmids were used as a control. b, Pie chart showing the distribution of BAZ2B-binding sites in genomic loci. TSS, the transcription start site. c, Profile heatmap around TSS of reference sequence (RefSeq) genes. Read counts were extracted for all ChIP-seq and ATAC-seq experiments within a region spanning ± 3 kb around TSS in livers of WT and Baz2b−/− CDAHFD-induced MASH mice. The heatmap showed the normalized results combined from three biological replicates. d, RNA-seq track of Pparα, Acsl1, Acadm, and Gls2 loci in livers of WT and Baz2b−/− CDAHFD-induced MASH mice.
