Extended Data Fig. 9: Hepatocyte-specific knock-down of Baz2b attenuates MASH pathology.
From: Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis
a, qPCR analysis of Baz2b expression in livers from young mice (2-3 months) fed with chow diet (control) or CDAHFD for 8 weeks. Baz2b mRNA levels were normalized to the level of Baz2b mRNA in livers of WT control mice. Experiment were repeated three times. b, Ratio (%) of liver to body weight of indicated mice. c, Heatmap showing qPCR analysis of changes in the expression of genes related to the Ppara signaling pathway, inflammation, and fibrosis. Red font highlights DEG with P < 0.05. d, e, Representative images (d) and quantifications (e) of CD11b and F4/80 staining in liver sections from indicated mice. Scale bar, 50 μm. f, g, Serum levels of AST (f) and ALT (g). The numbers of tested mice were indicated in parentheses. Each data point represents a value from one mouse. Data are means ± s.e.m. *P < 0.05, **P < 0.01 and ***P < 0.001. One-way ANOVA with Dunnett’s post-test was used for a-c and e-g.
