Fig. 5: Genetic FTLD CSF network module ORA with AD CSF networks. | Nature Aging

Fig. 5: Genetic FTLD CSF network module ORA with AD CSF networks.

From: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Fig. 5

Module member ORA of the genetic FTLD CSF network with two CSF protein co-expression networks in AD. Top: a multiplatform network, obtained using SomaScan and TMT-MS (Dammer et al.27). Bottom: a single platform network obtained using TMT-MS (Modeste et al.30). The box values represent −log10(FDR) value for pairwise module overlap, determined using one-tailed Fisher’s exact test. Bolded AD network modules significantly differed between AD and controls. Modules from the AD networks (y-axis rows) without an overlap value of −log10(FDR) >1 are not included in the heat maps. ***FDR P < 0.005, **FDR P < 0.01 and *FDR P < 0.05. The exact P values are reported in Supplementary Table 12.

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