Extended Data Fig. 3: Correlation of Genetic FTLD-associated Protein Effect Sizes with External AD and PD Datasets. | Nature Aging

Extended Data Fig. 3: Correlation of Genetic FTLD-associated Protein Effect Sizes with External AD and PD Datasets.

From: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Extended Data Fig. 3

a-f) Log2-fold changes of CSF SomaScan proteins with differential abundance in symptomatic FTLD gene carriers versus control (CTL) were correlated against CSF SomaScan protein effect sizes for AD versus CTL (A, C, E; log2-fold changes reported in Dammer et al.27) and PD versus CTL (B, D, F; regression coefficient weights reported in Rutledge et al.28). Correlations were performed using Pearson correlation. g) Genetic FTLD network module protein overlap with proteins increaed or decreased in AD or PD datasets. One-tailed Fisher’s exact test was used to determine module-wise enrichment, and results FDR-corrected using the Benjamini-Hochberg method. The exact p-values are reported in Supplementary Table 11.

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