Extended Data Fig. 1: Myeloid-biased hematopoiesis in aged mice.
From: Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function
(a) Frequency of myeloid, B, and T cells in peripheral blood (PB) from mice at 2, 12, 18, and 24 months (n = 5 per group). (b) Percentage of LT-HSCs in LSK (Lin–Sca1+cKit+) cells from mice at 2, 12, and 24 months (n = 3 per /group). (c) Percentage of common lymphoid progenitors (CLP) in LSlowKlow (Lin–Sca1lowcKitlow) cells from mice at 2, 12, and 24 months (n = 3 per group). (d, e) Representative FACS plots (d) and quantification (e) of CD41 or CD61 positive cells within the LT-HSCs in 2, 12, 24-month-old mice (n = 3 per group). One-way ANOVA with Dunnett’s multiple comparison test (a–c, e). Error bars represent mean ± SEM (a–c, e).
