Extended Data Fig. 3: TrnE mutation segregation in multiple organs and blood during aging.
a, Tail mutation load remained stable with aging (Two-tailed Wilcoxon test). b, Normalized mutation load of different organs from mutant TrnE mice at various age groups (3, 8, 24, 50, 75, and 100 weeks). The normalized organ mutation load was calculated as the organ’s mutation load divided by the tail’s mutation load from the same mouse. c, NBTx staining of different tissues (heart, liver, muscle, kidney and colon) from 50-week-old WT and TrnE high-mutant group.
