Extended Data Fig. 3: Over-representation analysis of significantly DEG in PD patients’ blood. | Nature Aging

Extended Data Fig. 3: Over-representation analysis of significantly DEG in PD patients’ blood.

From: A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression

Extended Data Fig. 3

(a) Table summarizing the number of significantly total, up-, and down-regulated DEG in the analyzed experimental groups, at visit 1 and visit 8 ((log2FC>|0.322|, that is 1.25 FC, and adj.p-value < 0.05). (b) Bar graph illustrating of the number of deregulated pathways detected performing ORA against different gene collections. (c, d) ORA based on the GO-BP collection for sufficiently powered groups at visit 1 (iPD, GBA and LRRK2 G2019S carriers, and prodromal cases’) and at visit 8 (iPD and GBA carriers) at visit 8. (e-m) ORA of significantly deregulated genes using the additional collection Reactome (e, f), Wikipathways (g, h), Hallmark(i, j), and KEGG (k, l). Upregulated pathways are represented in red, downregulated pathways in green.

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