Extended Data Fig. 7: Analysis for length-biased alterations in transcription output in additional datasets. | Nature Aging

Extended Data Fig. 7: Analysis for length-biased alterations in transcription output in additional datasets.

From: A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression

Extended Data Fig. 7

(a, b) Frequency plots of gene length of up- and downregulated genes (red and green trace respectively) in GBA patients at visit 8 and in G2019S LRRK2 carriers at visit 1. (c) Bar graph showing statistically significant biased deregulation of short vs. long genes in GBA patients, in a opposite direction than that observed in iPD at visit 8 (p.Wilcoxon, p < 0.0001 ****). (d) Summary table of statistical test results. The table reports z-statistics and corresponding p-values for each comparison. (ns p>0.05, *p<0.05, ****p<0.0001)

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