Extended Data Fig. 8: GSEA in iPD patients with different disease severity.

(a) UpSet graph showing the interactions between deregulated pathways as determined by KEGG based GSEA in patients exhibiting mild versus severe disease progression during the three years period of observation. Only one altered pathway is shared among the experimental groups, it relates to inflammation, and (b) the heatmap shows that it is upregulated in all conditions. (c) UpSet graph showing the interactions between deregulated pathways as determined by GO-BP based GSEA in patients exhibiting mild versus severe disease progression during the three years period of observation. (d) 16 altered pathways are shared among the experimental groups, they relate to transcription, translation, and mitochondrial function, and the heatmap shows that they are downregulated in all conditions. (e) UpSet graph showing that no shared deregulated pathways are detected using GSEA against WikiPathways. (f) Summary table of statistical test results. The table reports z-statistics and corresponding p-values for each comparison. (ns p>0.05, **** p<0.0001).