Fig. 8: Alterations in DNA damage and repair measures in independent datasets. | Nature Aging

Fig. 8: Alterations in DNA damage and repair measures in independent datasets.

From: A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression

Fig. 8

a, Frequency plots of the lengths of upregulated and downregulated genes (red and green traces, respectively) in the GSE99309 and GSE68719 datasets, which were derived from the blood and substantia nigra pars compacta, respectively (GSE99309, P = 0.000055; GSE68719P = 0.0000002). b, Bar graph illustrating biased suppression of longer genes in PD in both the blood and brain (two-sided Wilcoxon ****P < 0.0001). SN, substantia nigra. c, GSEA of the GSE99309 and GSE68719 datasets, which were generated from patients with a disease duration of >6 years, detected alterations that parallel those observed in iPD at visit 8. P-adj < 0.05. In GSEA, enrichment significance was assessed using a one-sided, permutation-based test on the NES, as implemented in the fgseaMultilevel function, which uses an adaptive multilevel Monte Carlo algorithm and includes multiple comparison corrections to estimate low P values efficiently.

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