Extended Data Fig. 6: Gene-based association results for brain age gap traits.
Manhattan plots (a-c) and quantile-quantile (QQ) plots (d-f) showing the results of the gene-based association analyses for the three brain age gap traits (n = 54,890 individuals of European ancestry). Manhattan plots display the P values (-log10 scale) of the tested genes on the y-axis and base-pair positions (gene start coordinates) along the chromosomes on the x-axis. In total, 18,639 protein-coding genes (RefSeq assembly GRCh37.p13, 09-05-2019) have been included. The solid horizontal line reflects the Bonferroni-corrected level of significance. The dashed horizontal line reflects the FDR-corrected level of significance. Diamonds and circles highlight the index gene in each genomic locus (diamonds: Bonferroni-significant index gene; red diamonds: Bonferroni-significant index gene exceeding the y-axis limit; circles: FDR-significant index gene). Genes within 3,000 kb of each other are considered to belong to the same locus and share the same index gene. Quantile-quantile plots show the observed P values from the association analysis vs. the expected P values under the null hypothesis of no effect (-log10 scale). For illustrative reasons, the y-axis has been truncated at p = 1.0e-40. a,d grey matter brain age gap (Manhattan and QQ); b,e white matter brain age gap (Manhattan and QQ); c,f combined brain age gap (Manhattan and QQ).
