Extended Data Fig. 7: Mendelian randomization analyses linking modifiable risk factors to brain age gap. | Nature Aging

Extended Data Fig. 7: Mendelian randomization analyses linking modifiable risk factors to brain age gap.

From: Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health

Extended Data Fig. 7

Results of the generalized summary-data-based Mendelian randomization (GSMR) results for 12 risk factors (exposures) and combined brain age gap (outcome). Each plot shows multiple genetic variants serving as instruments to test for causality between the exposure and outcome variable. Under a causal model, variant effects on the outcome (bzy; y-axis) are expected to be linearly proportional to the variant effects on the exposure variable (bzx; x-axis). The ratio between bzy and bzx provides an estimate of the mediation effect of x on y (bxy). Variants flagged for potential horizontal pleiotropy were excluded using the HEIDI-outlier method. s.e. standard error of the mediation effect; pxy P value of the mediation effect.

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