Extended Data Fig. 8: Relationship between genetic and phenotypic correlations of brain age gap with other complex traits. | Nature Aging

Extended Data Fig. 8: Relationship between genetic and phenotypic correlations of brain age gap with other complex traits.

From: Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health

Extended Data Fig. 8

This figure compares genetic and phenotypic correlation coefficients between brain age gap and 673 other complex traits. Genetic correlations were estimated using GWAS meta-analysis summary statistics for BAG (n = 54,890, European ancestry), while phenotypic correlations were calculated in the UK Biobank discovery sample (n = 32,634, European ancestry) using PHESANT. Summary statistics for other UK Biobank traits were obtained from Neale et al. (10.5281/zenodo.7186871). Results indicate a positive association between genetic and phenotypic correlation estimates. r: product-moment correlation coefficient, p: P value, MAD: mean absolute difference. (a) grey matter brain age gap, (b) white matter brain age gap, (c) combined brain age gap.

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