Extended Data Fig. 4: Functional partitioning of heritability for brain age gap.
Enrichment of heritability (h2) across functional genomic categories for (a) grey matter brain age gap, (b) white matter brain age gap, (c) combined brain age gap. Results are based on GWAS meta-analyses in individuals of European ancestry (n = 54,890). Heritability enrichment is defined as the proportion of h2 attributable to a given category divided by the proportion of SNPs in that category. Error bars represent jackknife standard errors around the estimates of enrichment. Please note that significance is tested based on the covariance matrix for the tau coefficient estimates (adjusted for all other baseline categories), which may differ from interpretations based solely on jackknife SEs. Functional categories are ordered by the proportion of SNPs they contain (x-axis), with percentages shown at tick marks. Categories with significant enrichment are marked by red diamonds.
