Table 1 Prediction accuracies of the stacked age estimation models stratified according to tissue class

From: Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health

 

UKB discovery (n = 32,634) 45–81 years

UKB replication (n = 21,881) 45–81 years

LIFE replication (n = 1,833) 45–80 years

r

R2

MAE

ICCBAG

r

R2

MAE

ICCBAG

r

R2

MAE

GM

0.827

0.683

3.372

0.899

0.825

0.676

3.405

0.888

0.828

0.653

3.990

WM

0.835

0.696

3.307

0.920

0.830

0.683

3.368

0.911

0.829

0.667

3.979

GM and WM

0.857

0.734

3.089

0.915

0.854

0.726

3.123

0.908

0.862

0.729

3.557

  1. The imaging data of the UKB discovery sample were released until January 2020 (release 1.7), whereas the data of the UKB replication sample were released until May 2024 (release 1.10). r indicates the product-moment correlation between brain-predicted age (without bias correction) and chronological age. R2 indicates the coefficient of determination (not equivalent to r2). ICCBAG indicates the ICC between the test and retest assessment of BAG. MAE is the MAE of brain-predicted versus chronological age. BAG was bias-corrected for age, age2, sex, scanner site and total intracranial volume. ICCs are based on a subset of 3,751 individuals in the UKB discovery sample and 395 individuals in the UKB replication sample.
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