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Towards a personalized approach in senolytic trials

Nature Aging (2025)Cite this article

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Attempts to translate senolytics from preclinical models to humans are gaining momentum. Early clinical trials have provided positive biological signals, but we lack clear evidence for the efficacy of senolytics in humans. Based on what we have learned in these initial trials, it may be time to aim for a more personalized approach in designing future senolytic trials, and potentially also in the eventual clinical use of these compounds.

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Fig. 1: Schematic summary of findings on the effects of D + Q on a serum marker of bone formation (P1NP) from the clinical trial by Farr et al.
Fig. 2: Working model for the possible interaction between senescent cell burden and potency of a senolytic intervention.

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Author information

Authors and Affiliations

  1. Division of Endocrinology, Mayo Clinic, Rochester, MN, USA

    Sundeep Khosla & David G. Monroe

  2. Robert and Arlene Kogo Center on Aging, Mayo Clinic, Rochester, MN, USA

    Sundeep Khosla & David G. Monroe

  3. Department of Medicine, University of Arizona, Tucson, AZ, USA

    Joshua N. Farr

Authors
  1. Sundeep Khosla
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  2. David G. Monroe
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  3. Joshua N. Farr
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Contributions

S.K. wrote an initial draft of the Comment, which was then edited by D.G.M. and J.N.F.

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Correspondence to Sundeep Khosla.

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The authors declare no competing interests.

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Nature Aging thanks George Kuchel and Tohru Minamino for their contribution to the peer review of this work.

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Khosla, S., Monroe, D.G. & Farr, J.N. Towards a personalized approach in senolytic trials. Nat Aging (2025). https://doi.org/10.1038/s43587-025-00964-5

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