Extended Data Fig. 6: Horizontal error bar plot of odds/hazard ratios of each aging biomarker and chronological age to aging-related diseases and all-cause mortality in the two validation cohorts.
From: OMICmAge quantifies biological age by integrating multi-omics with electronic medical records
a, Odds ratio of the TruDiagnostic Biobank. b, Hazard Ratio (left) and odds ratio (right) of the Generation Scotland. The ratios and 95% confidence intervals are based on a one- standard deviation change around the estimated mean values from the statistical models. Sample sizes (N) and the number of cases (n) for each phenotype are provided for the TruD (N1), and GS (N2) cohorts: Incident case: all-cause mortality, N2 = 18,672 (n2 = 1,503); type-2 diabetes, N2 = 18,488 (n2 = 589); stroke, N2 = 18,588 (n2 = 314); CVD (excl. stroke), N2 = 17,953 (n2 = 1,026); depression, N2 = 18,491 (n2 = 172); COPD, N2 = 18,535 (n2 = 492); cancer, N2 = 18,222 (n2 = 1,203). Prevalent case: type-2 diabetes, N1 = 14,213 (n1 = 299), N2 = 18,672 (n2 = 184); stroke, N1 = 14,213 (n1 = 115), N2 = 18,672 (n2 = 84); CVD (excl. stroke), N1 = 14,213 (n1 = 5,046), N2 = 18,672 (n2 = 719); depression, N1 = 14,213 (n1 = 1,329), N2 = 18,672 (n2 = 181); COPD, N1 = 14,213 (n1 = 45), N2 = 18,672 (n2 = 137); cancer, N1 = 14,213 (n1 = 1,501), N2 = 18,672 (n2 = 450).
