Fig. 6: Forest plot for the representation of the lifestyle factors associated with OMICmAge in the MGB-ABC and TruDiagnostic Biobank.
From: OMICmAge quantifies biological age by integrating multi-omics with electronic medical records
The effect size and 95% CIs, derived from the multivariate linear regression model, are shown as error bars for each lifestyle factor. All the associations are adjusted by chronological age, biological sex, ethnicity, BMI, tobacco use and alcohol consumption, when appropriate. The sample sizes (N) for each factor level across the MGB-ABC (N1) and TruD (N2) cohorts are presented below. FDR values are shown in parentheses for factor levels that are not the reference group (ref.). Biological sex: male (ref.), N1 = 1,158, N2 = 8,361; female, N1 = 2,064 (FDR = 5.51 × 10−128), N2 = 5,852 (FDR < 2.22 × 10−308). Race: white (ref.), N1 = 2,615, N2 = 12,114; Black, N1 = 241 (FDR = 1.75 × 10−15), N2 = 454 (FDR = 1.24 × 10−23); Asian, N1 = 53 (FDR = 0.473), N2 = 787 (FDR = 7.28 × 10−9); other, N1 = 237 (FDR = 0.026), N2 = 858 (FDR = 1.00 × 10−5). Education Level: did not complete high school (ref.), N1 = 46, N2 = 110; high school or associate degree, N1 = 516 (FDR = 0.343), N2 = 2,907 (FDR = 0.610); bachelor’s degree, N1 = 401 (FDR = 0.097); graduate degree, N1 = 493 (FDR = 0.005), N2 = 2,813 (FDR = 0.225). BMI class: underweight, N1 = 35 (FDR = 0.011), N2 = 396 (FDR = 0.170); normal weight (ref.), N1 = 763, N2 = 6,960; overweight, N1 = 971 (FDR = 0.011), N2 = 4,988 (FDR = 1.88 × 10−4); obesity, N1 = 1,355 (FDR = 0.140), N2 = 1,869 (FDR = 5.32 × 10−35). Exercise per week: no exercise (ref.), N1 = 444, N2 = 1,148; less than 5 h, N1 = 737 (FDR = 0.002), N2 = 7,477 (FDR = 1.47 × 10−8); 5 to 10 h, N1 = 155 (FDR = 6.41 × 10−6), N2 = 4,927 (FDR = 6.84 × 10−11); more than 10 h, N1 = 40 (FDR = 0.002), N2 = 552 (FDR = 3.29 × 10−7). Hours of sleep: less than 6 h (ref.), N1 = 47, N2 = 2,414; 6 to 9 h, N1 = 805 (FDR = 0.209), N2 = 10,358 (FDR = 0.008); more than 9 h, N1 = 299 (FDR = 0.847), N2 = 1,388 (FDR = 0.462). Smoking: non-smoker (ref.), N1 = 2,052, N2 = 13,652; current smoker, N1 = 192 (FDR = 5.13 × 10−8), N2 = 561 (FDR = 4.25 × 10−9); former smoker, N1 = 978 (FDR = 0.002). Alcohol: no alcohol (ref.), N1 = 1,609, N2 = 2,739; current drinker, N1 = 1,521 (FDR = 1.20 × 10−27), N2 = 11,474 (FDR = 0.610); former drinker, N1 = 21 (FDR = 0.769). Recreational drugs: never (ref.), N2 = 494; occasionally, N2 = 2,005 (FDR = 0.002). Interventions: antioxidants, N2 = 3,905 (FDR = 8.4 × 10−4); fish oil omega, N2 = 7085 (FDR = 5.25 × 10−6).
