Extended Data Fig. 1: Flowchart for inclusion of participants from the Massachusetts General Brigham (MGB) Biobank for the development of EMRAge, DNAmEMRAge and OMICmAge.
From: OMICmAge quantifies biological age by integrating multi-omics with electronic medical records
Among 60,370 MGB Biobank participants with plasma samples, 59,213 adults with verified vital status were retained after excluding individuals under 18 years and those with missing survival data. After exclusion of participants with missing non-imputable clinical variables, 29,222 individuals with complete data on 27 clinical phenotypes remained. These were encoded into 43 features, of which 19 significantly associated with mortality were selected to construct EMRAge, yielding a final cohort of 31,264 participants (training N = 21,885; test N = 9,379). A subset with available DNA methylation and proteomic data (N = 3,451) was used to develop DNAmEMRAge and OMICmAge (training N = 2,762; test N = 689). An independent subset with available PhenoAge (N = 17,252) was used for comparative analyses.
