Fig. 1: Distribution of the accessibility of 879 peptides.
From: Structural signature of plasma proteins classifies the status of Alzheimer’s disease
a, Workflow of CPP using the blood samples. b, Averaged accessibility decreased significantly across groups (healthy versus MCI: *P = 0.019, MCI versus AD: *P = 0.046, two-sided t-test). The box represents the IQR (25th–75th percentiles), center line, median, whiskers and 1.5× the IQR; outliers shown as individual points. c,d, Mean coefficient of variation (CV) for 879 labeled peptides (c) and 1,432 non-labeled peptides (d) in 520 individuals. The error bars indicate standard the deviation (*P = 0.0049, two-sided t-test). e, Peptides with significantly different accessibility (green) or intensity (blue) between groups (P < 0.05, two-sided t-test). The thick colors indicate significant proportions. f, Protein conformational changes compared as fold change between disease groups. Early accessibility changes showed stronger correlation with overall changes (R = 0.83) than late changes (R = 0.71). R signifies the Spearman’s correlation coefficient. The blue line represents the best-fit linear regression.
