Extended Data Fig. 5: Evaluation of cohort-specific bias.
From: Structural signature of plasma proteins classifies the status of Alzheimer’s disease
Cohort-specific bias was assessed by comparing the discriminatory power of UCSD (33 NOR, 17 MCI, 17 AD) and KUMC (34 NOR, 15 MCI, 31 AD) cohorts. The 3-marker panel classified NOR, MCI, and AD with accuracies of 89.55% (A) and 82.22% (B) for UCSD and KUMC cohorts, respectively. ROC curves were used to assess the classification AD against both MCI and NOR (C). The discriminatory powers were not significantly different between UCSD and KUMC for either NOR vs. AD (P-value = 0.31) or MCI vs. AD (P-value = 0.24) comparisons. The index values for the discriminatory power for each comparison were represented in the table.
