Extended Data Fig. 7: Assessing the confounding effect of age.
From: Structural signature of plasma proteins classifies the status of Alzheimer’s disease
“Age group” indicates groups based on age (young, middle, old), regardless of the disease (A). Statistical significance was determined by one-way ANOVA. Exact p-values are presented. Extremely low P-values below 0.0001 are reported as p < 0.0001. The average age within each group, divided by age, was significantly statistically different. “Original group” represents a group based on disease and was used as a test set when employing a multi-marker panel. The performance of the multi-marker panel showed very low distinguish power within the Age groups (B). Confusion matrices showing classification performance of the multi-marker panel in young (C) group (≦70 years, n = 46) and old (D) group ( > 70 year, n = 111). Numbers in each cell indicate the number of correctly or incorrectly classified samples. Diagonal cells (highlighted in yellow) represents correct classifications. Overall accuracy is shown below each matrix.
