Fig. 3: Sex-dependent associations of protein structure with NPSs.
From: Structural signature of plasma proteins classifies the status of Alzheimer’s disease
a, Simple linear regression analyses for male and female plotted as β coefficient versus −log(P). The labeled dots represent peptides showing significant accessibility–NPS relationships (P < 0.05) with sex differences. Red and blue represent positive and negative relationships. b, Twenty-six peptides showed significant NPS–accessibility relationships without sex influence. β coefficients were highly correlated between the sexes. c, Protein interaction network showing nine of ten proteins interacting with each other; PROS1 is not shown (no interactions). d, Four peptides from four proteins (CLUS, PROS1, ITIH2 and C3) in male participants, and five peptides from five proteins (FN1, CFB, HPX, CLUS and PROS1) in female participants showed AUROCs > 0.7 for both healthy versus MCI and MCI versus AD. VTVEKGSYYPGSGIAQF (PROS1) and SVDCSTNNPSQAKL (CLUS) showed AUROCs > 0.7 in both sexes. Diamonds indicate β coefficients; nonsignificant values are not shown. e, SVDCSTNNPSQAKL (CLUS) accessibility was significantly related to NPSs in both sexes using linear regression. No sex differences were observed. Blue and red indicate male and female. The shaded area indicates the 95% CI.
