Extended Data Fig. 3: Relation of NPS and structural change of protein.

NPS including agitation, anxiety, apathy, appetite, delusions, depression, disinhibition, elation, hallucination, irritability, motor disturbance, nighttime behaviors were considered. In the patient’s medical record, each symptom was scaled from 0 (none) to 3 (severe), the score for 12 symptoms were summed for each individual. There were 130 male participants (A), and 135 female participants (B). The proportion value represents the number of individuals with each summed score relative to the total number of individuals in the same disease group. ROC curves are presented for NOR vs. MCI (left) and MCI vs. AD (right) for DMENFRTEVNVLPGAKVQF of ITIH2 (C). Discriminatory power was different between male and female at the early stage (Delong’s test, P-value = 0.0115). Numbers in the square brackets are 95% confidence interval (CI). The shade area indicates 95% CI. Blue indicates male, red indicates female. ROC curves are presented for NOR vs. MCI (left) and MCI vs. AD (right) for SVDCSTNNPSQAKL of CLUS (D). AUROCs for SVDCSTNNPSQAKL of CLUS were over 0.7 for all classifications for both male and female. Blue indicates male, red indicates female.