Table 1 Demographic characteristics
From: Structural signature of plasma proteins classifies the status of Alzheimer’s disease
Healthy individuals (n = 227) | MCI (n = 135) | AD (n = 158) | |
|---|---|---|---|
Age (years) | 74.0 (6.7) | 74.0 (6.9) | 73.8 (9.4) |
Sex (male/female) | 99/128 | 73/62 | 82/76 |
BMI (kg m−2) | 27.3 (4.7) | 27.7 (4.9) | 27.1 (6.0) |
Aβ40 mean (pg ml−1) | 11,066 | 10,382 | 9,241 |
25th–75th percentiles | 8,230–13,705 | 7,310–12,238 | 7,130–11,166 |
Aβ42 mean (pg ml−1) | 786.60 | 709.40 | 415.50 |
25th–75th percentiles | 550–985 | 422–910 | 286–503 |
p-tau181 mean (pg ml−1) | 49.09 | 61.33 | 105.70 |
25th–75th percentiles | 30.55–59.55 | 30.5–92.8 | 57.6–125.2 |
T-tau mean (pg ml−1) | 345.50 | 437.10 | 772.00 |
25th–75th percentiles | 223–442 | 219–642 | 347–917 |
Ratio (Aβ42/Aβ40) mean | 0.07 | 0.07 | 0.05 |
25th–75th percentiles | 0.049–0.093 | 0.049–0.0931 | 0.0383–0.0567 |
APOE genotype (1/2/3/4/5)a | 50/31/16/2/0 | 29/26/1/8/1 | 32/35/6/17/2 |
Hypertension (absent/present) | 64/33 | 32/39 | 44/47 |
Hypercholesterolemia (absent/present) | 36/61 | 21/50 | 27/64 |
MMSE | 29.0 (1.1) | 26.5 (2.6) | 22.4 (4.9) |
CDRSUM | 0.1 (0.4) | 1.7 (0.8) | 5.5 (3.2) |
