Table 2 Model parameters
From: SimuCell3D: three-dimensional simulation of tissue mechanics with cell polarization
Symbol | Default dynamic | Default overdamped | Measured | Unit | Dimension | Description | Ref. |
|---|---|---|---|---|---|---|---|
Cell volume parameters | |||||||
ρ | 1,000 | 1,000 | 1,045–1,099 | kg m−3 | M/L3 | Mass density | |
K | 2,500 | 2,500 | 2,250 | Pa | M/LT2 | Bulk modulus | |
pmax | 2,500 | 2,500 | 300–2,200 | Pa | M/LT2 | Max. internal net pressure | |
Vmin | 3.7 × 10−16 | 3.7 × 10−16 | 2.5–3.7 × 10−16 | m3 | L3 | Min. volume (apoptosis) | |
Vmax | 1.4 × 10−15 | 1.4 × 10−15 | 0.9–1.3 × 10−15 | m3 | L3 | Max. volume (cell division) | |
g | 10−11 | 10−11 | 0.1–1.8 × 10−20 | m3 s−1 | L3/T | Volumetric growth rate | |
Cell surface parameters | |||||||
γ | 0.001 | 0.001 | 0.0005–0.0025 | N m−1 | M/T2 | Surface tension | |
kb | 2 × 10−18 | 2 × 10−18 | 1–2 × 10−18 | J | ML2/T2 | Bending stiffness | |
ka | 10−15 | 10−15 | — | J | ML2/T2 | Area elasticity modulus | — |
Q0 | 250 | 250 | 300 | — | — | Target isoparametric ratio | |
ξ | 109 | 109 | — | Pa m−1 | M/L2T2 | Repulsion strength | — |
ω | 109 | 109 | — | Pa m−1 | M/L2T2 | Adhesion strength | — |
Hmax | 5 × 106 | 5 × 106 | — | m−1 | 1/L | Max. coupling curvature | — |
Numerical parameters | |||||||
lmin | 2 × 10−7 | 2 × 10−7 | — | m | L | Minimum edge length | — |
c | 2 × 10−7 | 2 × 10−7 | — | m | L | Contact cutoff distance | — |
ζ | 2.5 × 10−10 | 3 × 10−9 | — | kg s−1 | M/T | Viscous damping coefficient | — |
Δt | 10−7 | 10−7 | — | s | T | Time step | — |
