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  • Perspective
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A perspective on brain-age estimation and its clinical promise

Nature Computational Science volume 4, pages 744–751 (2024)Cite this article

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Abstract

Brain-age estimation has gained increased attention in the neuroscientific community owing to its potential use as a biomarker of brain health. The difference between estimated and chronological age based on neuroimaging data enables a unique perspective on brain development and aging, with multiple open questions still remaining in the brain-age research field. This Perspective presents an overview of current advancements in the field and envisions the future evolution of the brain-age framework before its potential deployment in hospital settings.

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Fig. 1: The brain-age estimation framework.
Fig. 2: Advancements and challenges in the brain-age field.

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Acknowledgements

We gratefully acknowledge R. Dahnke for providing insightful comments on the paper and helping with the visualization. C.G. and P.K. were supported by Carl Zeiss Stiftung as a part of the IMPULS project (IMPULS P2019-01-006), the Federal Ministry of Science and Education (BMBF) under the frame of ERA PerMed (Pattern-Cog ERAPERMED2021-127) and the Marie Skłodowska-Curie Innovative Training Network (SmartAge 859890 H2020-MSCA-ITN2019).

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  1. These authors contributed equally: Christian Gaser, Polona Kalc.

Authors and Affiliations

  1. Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany

    Christian Gaser & Polona Kalc

  2. Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany

    Christian Gaser

  3. German Centre for Mental Health (DZPG), Jena-Halle-Magdeburg, Jena, Germany

    Christian Gaser

  4. Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK

    James H. Cole

  5. Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK

    James H. Cole

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  1. Christian Gaser
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Correspondence to Christian Gaser.

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J.H.C. is an advisor to and shareholder in BrainKey and ClaritasHealthPTE.

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Gaser, C., Kalc, P. & Cole, J.H. A perspective on brain-age estimation and its clinical promise. Nat Comput Sci 4, 744–751 (2024). https://doi.org/10.1038/s43588-024-00659-8

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