Predicting how molecular changes affect brain activity is a challenge in neuroscience. We introduced a multiscale modeling approach to simulate these microscopic changes and how they impact macroscale brain activity. This approach predicted how the anesthetic action on synaptic receptors can lead to the transitions in macroscale brain activity observed empirically.
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This is a summary of: Sacha, M. et al. A computational approach to evaluate how molecular mechanisms impact large-scale brain activity. Nat. Comput. Sci. https://doi.org/10.1038/s43588-025-00796-8 (2025).
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How molecular changes impact brain states and whole-brain activity: a multiscale approach. Nat Comput Sci 5, 442–443 (2025). https://doi.org/10.1038/s43588-025-00813-w
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DOI: https://doi.org/10.1038/s43588-025-00813-w
