Fig. 1: S1 drug sensitivity profiles in pure and mixed culture growth conditions alongside species S2. | ISME Communications

Fig. 1: S1 drug sensitivity profiles in pure and mixed culture growth conditions alongside species S2.

From: Predicting the re‐distribution of antibiotic molecules caused by inter‐species interactions in microbial communities

Fig. 1

A Growth of species S1, with different parameter values (k1 \(\bar \mu\)1, and y1), after 24 h of growth in the presence of different antibiotic concentrations. I aggregated the resulting dose‐response profiles (blue) to create a density map from low predicted cell density (white) to high predicted cell density (black). B–D IC90, antibiotic concentration inhibiting 90% (IC90) the growth predicted without drug, resulting with different parameters values for the half‐saturation parameter k1 (B), maximal carbon up‐take \(\bar \mu\)1 (C), or biomass yield y1 (D) in eq. 1 when species S2 is drug‐sensitive. The IC90 for species S1 growing as pure cultures is shown in grey, and growing in mixed culture with S2 are shown in black. The parameter values for species S2 were fixed at a value noted by a black arrow on the y‐axis, followed by a dotted black line. E–G Change in IC90, as in Fig. (B–C), when the competing species S2 is not drug‐sensitive (resistant or tolerant). Parameter values used can be found in Table 1.

Back to article page