Fig. 2: 3CB, lipid, water, and protein, data, and regions of feature extraction.

a Full presentation mammogram image and the derived three-compartment breast (3CB) thickness maps. From left to right is the standard presentation craniocaudal mammogram used for reading by a radiologist, lipid thickness map, water thickness map, and protein thickness map. Grayscale colorbars, adjacent to 3CB thickness maps, indicate thickness in cm. b The composition of the background or tissue surrounding a lesion was measured progressively by capturing three outer regions extending from the border of the lesion (yellow solid line). The outer regions extend from the lesion border at distances of 2 mm (orange dot-dashed line), 4 mm (cyan dotted line), and 6 mm (magenta dashed line). c Computer-aided detection (CAD) delineations that had some agreeance with radiologist region of interest (ROIs) (yellow line) were included in the final data set. CAD delineates suspicious masses (cyan dot-dashed line) and calcification clusters (magenta dotted line). Outer regions for all ROIs (radiologist and CAD delineated) were calculated but not displayed in this sub-figure for easy viewing.