Fig. 5: Lesion composition characterization.

Differences between median composition values of the lesion and the outer regions were calculated for all radiologist region of interest (ROI)s. Column one (a, d, g), two (b, e, h), and three (c, f, i) compares the composition within the lesion to the region 2, 4, and 6 mm from its border respectively. Each row looks at a different compositional component, lipid (a, b, c), water (d, e, f), or protein (g, h, i). Calculated differences are stratified by the following lesion types: benign (green), fibroadenoma (blue), ductal carcinoma in situ (DCIS) (orange), and invasive ductal carcinoma (invasive) (red). Median values of all benign lesions types, benign and fibroadenoma, and malignant types, DCIS and invasive, are represented by blue and orange dashed lines respectively. Gray line indicates zero and ROIs that lay above this line have more of a given composition when compared to its corresponding background outer region. Boxes represent the 25–75% interquartile range and the center line represents the median. Whiskers represents 1.5 the interquartile range and outliers which fall outside that range are depicted as diamonds.