Fig. 6: Hormone receptor composition characterization.

Compositional difference between invasive regions of interest (ROI) and their background are stratified by hormone receptor status. Each column of panels corresponds to the compositional signature at 2 (a, d, g), 4 (b, e, h), and 6 (c, f, i) mm from the lesion border while each row of panels corresponds to lipid (a, b, c), water (d, e, f), or protein (g, h, i). Median compositional difference between receptor-positive and triple-negative cancers are indicated by the blue and orange dashed lines, respectively. Receptor-positive median was calculated by including all lesion that contained either estrogen receptor (ER), progesterone (PR), or human epidermal growth factor receptor 2 (HER2) receptor status. Each subplot panel contains box and whisker plots for ER+ (blue), PR+ (orange), HER2+ (green), ER+/PR+ (red), ER+/PR+/HER2+ (purple), and triple-negative (brown) receptor statuses from left to right. Boxes represent the 25–75% interquartile range and the center line represents the median. Whiskers represents 1.5 the interquartile range and outliers which fall outside that range are depicted as diamonds.