Table 3 Net reclassification with respects to BI-RADS risk categories.

From: Dual-energy three-compartment breast imaging for compositional biomarkers to improve detection of malignant lesions

Reference (CAD)

Events (CAD + 3CB)

Non-events (CAD + 3CB)

BI-RADS thresholds (risk range)

3 (0–≤2%)

4a (2–≤10%)

4b (10–≤50%)

4c & 5 (>50%)

Total

3 (0–≤2%)

4a (2–≤10%)

4b (10–≤50%)

4c & 5 (≥50%)

Total

3 (0–≤2%)

0

0

0

1

1

0

0

0

0

0

4a (2–≤10%)

0

0

1

0

1

2

2

8

3

13

4b (10–≤50%)

0

0

9

8

17

0

6

51

9

66

4c & 5 (≥50%)

0

0

11

20

31

0

5

47

13

65

Total

0

0

21

29

50

2

13

106

25

146

  1. This table shows that adding 3CB allows for more accurate BI-RADS classification, as determined by probability of malignancy, for lesions with both malignant and non-malignant pathologies or events and non-events. The NRI for events and non-events is −0.02 and 0.25. The overall NRI, which is the sum of NRI events and non-events, is 0.25.
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