Fig. 4: SARS-CoV-2 transcriptome diversity.
From: Reduced subgenomic RNA expression is a molecular indicator of asymptomatic SARS-CoV-2 infection
a Proposed models of the origins of SARS-CoV-2 genomic deletions resulted from the lack of accurate replications of viral gRNAs (Right) or transcription of viral sgRNA (Left). b Assignment of full-length (FL) transcript units (TUs) revealed by long-read Iso-seq into viral sgRNAs (n = 1114), gRNAs (n = 4591), or undefined (n = 9539) based on their spans across transcription regulatory sequence (TRS) -Leader/-Body (TRS-L/TRS-B) junctions. c The distribution of FL TUs assigned to different sgRNA species based on their corresponding TRS-B sites.
