Table 1 AGDS demographics and side effect prevalence across medications.
From: Understanding genetic risk factors for common side effects of antidepressant medications
Males N | Females N | Sex p-valuea | Endorsed side effect age (s.d.) | Not endorsed side effect age (s.d.) | Age p-valueb | |
|---|---|---|---|---|---|---|
N | 5111 | 15830 | — | — | — | — |
Age mean (s.d.) | 47.99 (15) | 41.41 (14) | 6.6e−160 | — | — | — |
Reduced sexual desire | 2251 (44%) | 6264 (39%) | 1.5e−08 | 41.0 (13.98) | 44.4 (16.01) | 1.1e−58 |
Weight gain | 1402 (27%) | 5695 (35%) | 3.2e−29 | 41.9 (13.89) | 43.6 (15.96) | 1.1e−13 |
Dry mouth | 1236 (24%) | 4544 (28%) | 3.2e−10 | 42.7 (14.20) | 43.1 (15.71) | 0.071 |
Nausea | 867 (16%) | 4352 (27%) | 1e−51 | 37.7 (13.34) | 44.8 (15.52) | 1.6e−187 |
Headaches | 704 (13%) | 3282 (20%) | 3.1e−28 | 38.3 (13.74) | 44.1 (15.45) | 2e−106 |
Dizziness | 959 (18%) | 3930 (24%) | 5.2e−19 | 38.4 (13.43) | 44.4 (15.57) | 5.3e−130 |
Shakes | 571 (11%) | 2466 (15%) | 7.4e−15 | 38.8 (14.22) | 43.7 (15.37) | 3.8e−62 |
Muscle pain | 234 (4%) | 837 (5%) | 0.045 | 42.0 (14.98) | 43.1 (15.33) | 0.029 |
Sweating | 997 (19%) | 3291 (20%) | 0.048 | 40.3 (13.75) | 43.7 (15.61) | 6.8e−38 |
Vomit | 147 (2%) | 826 (5%) | 4.7e−12 | 35.7 (12.65) | 43.4 (15.34) | 6e−53 |
Constipation | 395 (7%) | 1489 (9%) | 2.70E−04 | 43.3 (15.01) | 43.0 (15.34) | 0.440 |
Diarrhoea | 368 (7%) | 1176 (7%) | 0.590 | 39.9 (13.87) | 43.3 (15.39) | 8.8e−17 |
Drowsiness | 1173 (22%) | 3709 (23%) | 0.480 | 39.7 (14.30) | 44.0 (15.46) | 6.8e−67 |
Trouble sleeping | 1052 (20%) | 3672 (23%) | 1.00e−04 | 39.6 (14.35) | 44.0 (15.43) | 2.3e−70 |
Anxiety | 794 (15%) | 2973 (18%) | 1.5e−07 | 39.1 (14.24) | 43.9 (15.40) | 1.6e−68 |
Agitation | 786 (15%) | 2816 (17%) | 7.2e−05 | 39.6 (14.12) | 43.7 (15.45) | 1.3e−50 |
Fatigue | 912 (17%) | 3181 (20%) | 4.20e−04 | 39.4 (14.49) | 43.9 (15.38) | 8.4e−63 |
Weight loss | 157 (3%) | 795 (5%) | 5.9e–09 | 36.1 (13.42) | 43.3 (15.32) | 5.1e−47 |
Rashes | 97 (1%) | 257 (1%) | 0.190 | 45.5 (14.96) | 43.0 (15.31) | 0.002 |
Runny nose | 82 (1%) | 344 (2%) | 0.012 | 44.9 (15.64) | 43.0 (15.30) | 0.010 |
Blurry vision | 266 (5%) | 1012 (6%) | 0.002 | 42.6 (14.60) | 43.0 (15.35) | 0.280 |
Suicide thoughts | 699 (13%) | 2560 (16%) | 1.9e−05 | 38.2 (14.24) | 43.9 (15.33) | 4.7e−87 |
Suicide attempt | 248 (4%) | 1090 (6%) | 2.4e−07 | 35.9 (13.41) | 43.5 (15.31) | 4.5e−69 |
Other side effects | 632 (12%) | 1968 (12%) | 0.900 | 41.3 (14.05) | 43.3 (15.47) | 1.3e−09 |
No side effects | 334 (6%) | 1140 (7%) | 0.110 | 43.8 (15.04) | 43.0 (15.33) | 0.044 |
