Table 2 Polygenic prediction of specific side effects across medications.

From: Understanding genetic risk factors for common side effects of antidepressant medications

Antidepressant

BMI PRS predicting weight gain

Insomnia PRS predicting trouble sleeping

Headaches PRS predicting headaches

OR (95%C.I.)

P-value

Variance explained (%)

OR (95%C.I.)

P-value

Variance explained (%)

OR (95%C.I.)

P-value

Variance explained (%)

Sertraline

1.24 (1.17–1.32)

4.66e-12

1.25

1.06 (0.99–1.14)

0.077

0.09

1.16 (1.08–1.25)

8.17e-05

0.49

Escitalopram

1.21 (1.13–1.29)

3.58e-08

1.01

1.12 (1.03–1.21)

0.008

0.27

1.06 (0.97–1.16)

0.178

0.08

Venlafaxine

1.20 (1.12–1.28)

3.72e-07

0.93

1.03 (0.95–1.11)

0.463

0.02

1.11 (1.01–1.21)

0.025

0.22

Amitriptyline

1.25 (1.12–1.40)

9.84e-05

1.38

1.28 (1.07–1.52)

0.007

1.03

1.09 (0.93–1.28)

0.268

0.15

Mirtazapine

1.20 (1.09–1.32)

2.03e-04

0.95

1.03 (0.88–1.20)

0.745

0.01

1.04 (0.90–1.20)

0.560

0.04

Desvenlafaxine

1.22 (1.11–1.33)

3.01e-05

1.03

1.13 (1.03–1.25)

0.015

0.38

1.08 (0.98–1.20)

0.126

0.16

Citalopram

1.37 (1.24–1.50)

9.06e-11

2.5

1.08 (0.96–1.21)

0.194

0.12

1.11 (0.98–1.26)

0.088

0.23

Fluoxetine

1.26 (1.17–1.36)

5.75e-09

1.42

1.03 (0.94–1.13)

0.523

0.02

1.02 (0.93–1.12)

0.689

0.01

Duloxetine

1.20 (1.08–1.32)

3.60e-04

0.94

1.14 (1.02–1.28)

0.026

0.4

1.03 (0.92–1.15)

0.626

0.02

Paroxetine

1.22 (1.09–1.36)

6.28e-04

1.1

1.16 (1.01–1.33)

0.042

0.47

1.16 (1.00–1.35)

0.053

0.46

  1. Results from logistic regressions predicting weight gain, trouble sleeping and headaches using BMI, Insomnia and headaches PRS respectively. Bolded p-values represent values significant after multiple testing correction (p < 0.005). Results shown for SBayesR, for clumping and thresholding sensitivity results see Supplementary Data.
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