Fig. 2: Results from the PGS associations with disease endpoints in the FinnGen.
From: Genetic analyses implicate complex links between adult testosterone levels and health and disease
a Illustrates the distribution of association p-values by disease category for each biomarker PGS separately for both sexes. For clarity p values capped at 1e-20. Dark green symbol = males, pink = females. Green circles = total testosterone, white lilac = SHBG, blue = free testosterone. b Shows hazard ratios per one SD increase in PGS for 20 traits from endocrine, metabolic, circulatory and sex-specific categories. Yellow shades = increased risk for endpoint, blue shades = decreased risk for endpoint. The data is based on 94,478 men and 122,986 women from FinnGen R5. Case and control numbers for each endpoint are available from Supplementary Data 7. *p < 0.05, **p < 0.0014, corresponding to Bonferroni correction for 36 independent traits. PCOS polycystic ovary syndrome, PMB post-menopausal bleeding, CHD coronary heart disease.
