Table 1 Description of the reporter virus particles (RVPs) used in the pseudovirus neutralization assay.
Pango Lineage | WHO Name | Strain (Nextstrain) | Sequence source | Catalog number | Lot | Mutations relative to Wuhan D614 |
|---|---|---|---|---|---|---|
A | N/A | Wuhan (reference sequence) – D614 | GenBank QHD43416.1 | RVP-701 | CG-113A | - |
B.1 | N/A | D614G | - | RVP-702G | CG-129A | D614G |
B.1.1.7 | Alpha | 20I/S:501Y.V1 | QQH18545.1 | RVP-706G | CG-135A | ΔH69/V70, ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H |
B.1.351 | Beta | 20H/S:501Y.V2 | Tegally et al. 2020 | RVP-724G | CG-180A | L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, E484K, N501Y, D614G, A701V |
P.1 or B.1.128 | Gamma | 20J/S:501Y.V3 | QQX12069.1 | RVP-708G | CG-160A | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176 |
B.1.617.2 | Delta | 21A/S:478K | cov-lineages.org | Custom | CG-233A | T19R, G142D, E156G, ΔF157/R158, L452R, T478K, D614G, P681R, D950N |
B.1.621 | Mu | 21H | QXK87114.1 | RVP-767G | CG-273A | T95I, Y144T, Y145S, ins146N, R346K,E484K, N501Y, P681H, D614G |
BA.1 | Omicron BA.1 | 21K | EPI_ISL_6841980 | RVP-768G | CG-296A | A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
BA.4/5 | Omicron BA.4/5 | 22B | UTO31503.1 | RVP-774G | CG-352A | T19I, LPPA24S, HV69del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K |
NA | NA | SARS-CoV-1 | P59594.1 | RVP-801G | SG-115B | 28% differences |
