Table 2 Comparison of results from approaches that did (columns) and did not (rows) account for the strong correlation between BCAAs when estimating effects with 441 phenotypes spanning 17 categories in a maximum of 97,469 UK Biobank European ancestry participants.

From: Branched chain amino acids harbor distinct and often opposing effects on health and disease

  

No. of phenotypes with significant total causal effect with 0, 1, 2, or 3 BCAAsb,c

  

0

1

2

3

Total

N. of phenotypes with significant total effect with 0, 1, 2, or 3 BCAAsa,b

0

275

6

3

1

285

1

13

5

5

1

24

2

9

4

3

3

19

3

27

37

29

20

113

Total

324

52

40

25

441

  1. aUsed univariable Mendelian randomization that did not account for correlation between BCAAs.
  2. bAll statistical models adjusted for ancestral principal components, study center, age, and sex
  3. cEstimated using MVMR statistical approach that accounted for correlation between BCAAs. BCAA, branched chain amino acid. MVMR, multivariable Mendelian randomization.
Back to article page