Fig. 7: Cytokines concentration from right lung bronchoalveolar lavage (BAL).

Higher alveolar concentration of the acute phase inflammatory cytokines IL-6 (a), IL-1β (b) and TNF-α (c) were measured in the right lung of NVLI-15 vs. NVLI-7.5 and MV-Control groups. BAL concentrations of the endothelial inflammatory marker Ang2 (d) were higher in the right lung in the NVLI-15 group vs. the other 2 groups, while concentrations of epithelial inflammatory markers sRAGE (e) and SP-D (f) didn’t differ between groups. Data are expressed as scatter plot with bars and error bars (mean ± SEM). Comparisons were performed by Kruskal-Wallis test for non-normally distributed values (P-value reported in the graph) followed by Dunn’s multiple comparisons test (§p < 0.05 vs. NVLI-15 group). Sample size: NVLI-15 group n = 10; NVLI-7.5 n = 11; MV-Control n = 6.