Fig. 5: Distinct immune cell phenotypic patterns between non-B57 and B57 ECs with an individual profile displayed by each patient in these subgroups.
From: Early elevated IFNα is a key mediator of HIV pathogenesis
a Comparative analysis of NK cells, CD4+ and CD8+ T-cell subset distribution in non-B57 and B57 ECs. aI PCA of studied non-B57 (ECB57−) and B57 (ECB57+) ECs based on the proportion of CD4+, CD8 + T cells, NK cells, and their subpopulations, evaluated by flow cytometry. Each point represents one participant, color-coded by group: ECB57− (blue), ECB57+ green). aII Heatmaps show the distribution of the indicated lymphocyte subsets in ECs. b Differential expression of checkpoint molecules on mature NK cells and different subsets of CD8+ T cells. Histograms show the frequency and index ratio of indicated subsets in mature NK (bI–III) and CD8+T cell compartments (bIV–VI). c Heatmaps of the frequency of indicated markers in CD4+ Treg, CD4+CM, CD8+CM, CD8+CTL, CD8+supp, and mature NK cells. Warmer colors indicate higher values and colder colors indicate lower values. Comparisons between the two groups were performed with the Mann–Whitney U-test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns not significant.
