Fig. 3: The expression of small ncRNAs in the eight FF-sEVs from three patients. | Communications Medicine

Fig. 3: The expression of small ncRNAs in the eight FF-sEVs from three patients.

From: Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology

Fig. 3

a The clustering and heatmap analysis of the small ncRNA profiling in FF-sEVs. b The PCA of the small ncRNA profiling shown in (a). The arrows indicate the association between the FF-sEVs with non-pregnant and pregnant in each patient. Blue and red circles indicate the non-pregnant FF and pregnant FF, respectively. PC means principal component. c The normalized read counts of miR-16-2-3p, miR-378a-3p, and miR-483-5p. The arrows indicate the association between the FF-sEVs with non-pregnant and pregnant in each patient. Blue and red circles indicate the non-pregnant FF and pregnant FF, respectively. d Functional annotation of the selected three miRNAs (miR-16-2-3p, miR-378a-3p, and miR-483-5p) and embryo quality-associated genes. Yellow and green circles indicate the embryo quality-associated genes and the target genes of miR-378a-3p, miR-16-2-3p, and miR-483-5p, respectively. GO terms were listed with P values.

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