Table 1 The basic information of GWAS summary data used in two-sample Mendelian randomization validation
Traits (Ref code) | Sample size (n) | Significant threshold | SNPs (n) | Heritability (SE) |
|---|---|---|---|---|
TRS (/) | 30,826 | 5 × 10−6 | 9 | 0.013 (0.006) |
Phosphate (met-a-364) | 7789 | 5 × 10−5 | 19 | 0.107 (0.010) |
Gamma-glutamyltransferase (ukb-e-30730_CSA) | 8422 | 5 × 10−5 | 93 | 0.197 (0.025) |
Reticulocyte percentage (ukb-d-30240_irnt) | 344,728 | 5 × 10−8 | 288 | 0.179 (0.014) |
Total protein (bbj-a-56) | 113,509 | 5 × 10−8 | 36 | 0.137 (0.009) |
Mean corpuscular volume (ukb-d-30040_irnt) | 350,473 | 5 × 10−8 | 378 | 0.234 (0.026) |
Mean corpuscular hemoglobin (ukb-d-30050_irnt) | 350,472 | 5 × 10−8 | 366 | 0.229 (0.028) |
Reticulocyte count (ukb-d-30250_irnt) | 344,729 | 5 × 10−8 | 291 | 0.180 (0.013) |
Glycated hemoglobin (HbA1c) (ukb-e-30750_CSA) | 8329 | 5 × 10−8 | 5 | 0.188 (0.016) |
Lymphocyte count (ukb-d-30120_irnt) | 349,856 | 5 × 10−8 | 343 | 0.171 (0.011) |
Cholesterol (ieu-a-301) | 187,365 | 5 × 10−8 | 88 | 0.222 (0.028) |
Red blood cell (erythrocyte) count (ukb-d-30010_irnt) | 350,475 | 5 × 10−8 | 358 | 0.196 (0.016) |
Creatinine (ieu-a-1105) | 133,814 | 5 × 10−8 | 47 | 0.094 (0.007) |
