Fig. 5: Proteins related to SARS-CoV-2 infection.
From: Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections
a Least absolute shrinkage and selection operator (LASSO) analysis shortlisted proteins differentiating seropositive (N = 37) and seronegative (N = 44) subjects in study 1. The y-axis represents the centered and scaled data provided as normalized protein expression (NPX) values. b Ranked importance score of selected proteins. c Using the STRING database, we identified interactions between the selected features and obtained a network centered around acute phase processes and innate immunity, host-virus interactions, coagulation, and cellular adhesion. d LASSO selected proteins from study 2 comparing donors representing the early (N = 22) and late infection phases (N = 41), and (e) corresponding importance scores. f LASSO selected proteins from study 3, comparing seropositive (N = 40) and seronegative donors (N = 37). The boxplots show the 25% and 75% quantiles (lower and upper hinges) with the median in the center, the whiskers extending to hinges ±1.5× interquartile ranges (IQR), and visible data points outside these ranges.
