Fig. 5: Shared genetic architecture at COVID-19 risk loci.
From: Complex patterns of multimorbidity associated with severe COVID-19 and long COVID
a Network representation of significant (PP > 80%) colocalization results. Loci are depicted as white rectangles and diseases as coloured nodes according to ICD-10 chapters. Edges represent strong evidence for colocalization, and solid lines indicate a risk-increasing effect of the COVID-19 risk increasing allele, whereas dashed lines indicate protective effects. Underlying data can be found in Supplementary Data 8. b Forest plot displaying hazard ratios (rectangle) with 95%-confidence intervals (lines) for each variant and different COVID-19 and colocalising disease outcomes. Effect estimates for COVID-19 have been obtained from the COVID-19 Host Genetic Initiative and effect estimates for diseases in the present study. All estimates are derived from logistic regression models. c Heatmap of effect estimates across 49 independent genetic loci associated with increased risk for sever COVID-19 and corresponding effects on six selected traits that showed evidence of colocalization at least one other locus. Black rectangles indicate genome-wide significant effects (p < 5 × 10−8). NOS not elsewhere specified; All underlying data can be found in Supplementary Data 1 and 8 or is given in the data availability statement.
