Table 1 Root mean square error of simulated naloxone kinetics in the body after nasal administration

From: Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal

Naloxone Dose (mg)

Root Mean Square Error

As a percentage of peak concentration

2

0.324

12

4

0.806

14

8

1.08

11

16

2.36

17

  1. Validation data was used to fit the kinetic model for the 2 mg dose. The error term is an average vertical distance between the validation data and simulated data. The percentage is computed by scaling the error term by the maximum naloxone concentration value.
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