Table 2 Details on experimental data used to validate the fentanyl patient response in the physiology engine

From: Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal

Route

Concentration

Total Dose (ug)

Reference

Infusion (5 minutes)

50 ug/mL

100 ug

61

Bolus (2-minute delay)

50 ug/mL

200 ug

62

Infusion (10 minutes)

50 ug/mL

5 ug/kg (350 ug for virtual patient)

63,64

Bolus

50 ug/mL

500 ug

50,65

  1. Data digitally extracted from figures. Data from66 was omitted as the magnitude of the blood plasma curves indicated instrumentation error, or large deviations due to age of the study.
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